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      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
        <publisher-name>Radiance Research Academy</publisher-name>
      <article-id pub-id-type="publisher-id">5</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2021.1103</article-id>
      <article-id pub-id-type="doi-url"/>
        <subj-group subj-group-type="heading">
        <article-title>Effect of High and Low Caffeine Dosage Regimens on Mortality in Preterm Infants: A Systematic Review&#13;
        <contrib contrib-type="author">
      <pub-date pub-type="ppub">
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        <p>There is growing controversy regarding the effect of caffeine dose administration in preterm infants as it relates to the clinical outcomes of managing apnea in preterm births. This study aimed to conduct a systematic review to investigate the effect of caffeine dosage regimens on decreasing mortality and potential morbidities in preterm infants. Randomized controlled trials that compared the high and low caffeine doses in a preterm infantile population were included in this study. A search of relevant databases using appropriate search terms was utilized to identify all relevant studies. A total of nine trials were included in the review. Among these studies, six trials reported that high caffeine dose administration does not significantly increase the risk of mortality. Moreover, based on the results of six studies, it is indicated that a high-dose regimen is not associated with the development of chronic lung diseases in preterm infants at 36 weeks of corrected age. Studies also demonstrated that the duration of the apneic spells were much higher in the low than the high dose groups. Other adverse events including necrotizing enterocolitis and intracranial hemorrhages were reported but were not of statistical significance. Although the current findings support the administration of high caffeine doses in preterm infants, further investigations are needed for further validation of the current evidence.&#13;