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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="dentistry" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">480</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2025.51220</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Dentistry</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Implant Survival in Sites With Previous Endodontic Failure and Apical Pathology&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Alghamdi</surname>
            <given-names>Anwar Salih</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>AlGhamdi</surname>
            <given-names>Abdulhakeem Mohammad</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Al-Enezi</surname>
            <given-names>Haifa Tuwairish</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alhumaily</surname>
            <given-names>Hasan Abdullah</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>24</day>
        <month>12</month>
        <year>2025</year>
      </pub-date>
      <volume>5</volume>
      <issue>12</issue>
      <fpage>871</fpage>
      <lpage>876</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Periapical pathology resulting from endodontic failure poses a significant challenge for subsequent implant placement. The altered biological environment in such sites includes chronic inflammation, residual microbial contamination, and compromised bone architecture, all of which can affect implant integration and long-term stability. Although clinical and radiographic healing may suggest resolution, histological studies often reveal lingering inflammatory responses and microbial remnants within the bone and soft tissues. These factors can impair osseointegration and increase the risk of early implant complications, including peri-implantitis and marginal bone loss. Multiple variables influence the success of implants placed in previously infected sites. These include the timing of implant placement, the degree of surgical debridement, and the use of regenerative materials to restore lost bone. Delayed placement after complete healing has shown more predictable outcomes compared to immediate implantation, primarily due to reduced microbial load and improved soft and hard tissue conditions. Adjunctive measures such as photodynamic therapy, guided bone regeneration, and modified drilling protocols have been introduced to enhance clinical outcomes in these compromised sites. Despite the inherent risks, studies have reported comparable implant survival rates between previously infected and non-infected sites when proper protocols are followed. Customizing surgical techniques and material selection based on site-specific conditions is critical. Evaluating the biological history of the site, not just its structural readiness, remains essential for achieving favorable outcomes. Understanding the interplay between past infection and current healing dynamics informs clinical decision-making and improves the predictability of implant therapy in these complex scenarios.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd> endodontic failure</kwd>
        <kwd> apical pathology</kwd>
        <kwd> dental implants</kwd>
        <kwd> osseointegration</kwd>
        <kwd> peri-implantitis</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>