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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="gastroenterology" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">476</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2025.51216</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Gastroenterology</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Acute Gastrointestinal Complications in Patients with Severe Sepsis: Incidence, Recognition, and Outcomes&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Fadda</surname>
            <given-names>Nader Saber</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>AlFudhayli</surname>
            <given-names>Ali Waleed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alzuraiq</surname>
            <given-names>Khalid Abdulrhman</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Yahya</surname>
            <given-names>Nawaf Ahmad</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alalawi</surname>
            <given-names>Mohammed Saeed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alfaraj</surname>
            <given-names>Hassan Ali</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Habis</surname>
            <given-names>Hassan Muwafak</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alshbeni</surname>
            <given-names>Ali Ahmed</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>23</day>
        <month>12</month>
        <year>2025</year>
      </pub-date>
      <volume>5</volume>
      <issue>12</issue>
      <fpage>839</fpage>
      <lpage>847</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Sepsis refers to a life-threatening organ dysfunction that occurs due to a dysregulated systemic inflammatory response to infection. It is associated with high morbidity and mortality rates. Sepsis severity depends on the number of organ failures and the presence of septic shock. Acute gastrointestinal complications are common in severe sepsis patients due to reduced gastrointestinal microcirculatory blood flow, systemic inflammation, and disruption of the gut barrier. Gut barrier disruption is a central event in the pathophysiology of gastrointestinal complications in severe sepsis patients. It allows for bacterial translocation into the systemic circulation, which affects the liver and other organs, and further exacerbates systemic inflammation. The most frequent gastrointestinal complications in severe sepsis patients include gastrointestinal dysmotility, gastrointestinal bleeding, and acute liver injury. These complications, especially sepsis-induced liver injury, are associated with poor outcomes and higher mortality rates. Moreover, severe sepsis patients who develop such complications require tailored management, which further complicates sepsis treatment. Novel therapeutic approaches are required for effective management of sepsis-associated gastrointestinal complications. In this narrative review, we aim to outline current knowledge regarding the most common acute gastrointestinal complications encountered in severe sepsis patients, focusing on their incidence, recognition, and outcomes, highlighting the role of the gut barrier in the pathophysiology of these complications.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>severe sepsis</kwd>
        <kwd> septic shock</kwd>
        <kwd> systemic inflammation</kwd>
        <kwd> gut barrier disruption</kwd>
        <kwd> bacterial translocation</kwd>
        <kwd> sepsis-induced liver injury</kwd>
        <kwd> gastrointestinal complications</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>