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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="endocrinology" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">468</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2025.51208</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Endocrinology</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>The Impact of Genetic Variations on the Success Rates of Endodontic Treatments&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname/>
            <given-names/>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alhefdi</surname>
            <given-names>Hatim Mohammed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alhashem</surname>
            <given-names>Fatemh Mousa</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alqarni</surname>
            <given-names>Mohammed Abdullah</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alwusaybie</surname>
            <given-names>Mahdi Mohammed</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>14</day>
        <month>12</month>
        <year>2025</year>
      </pub-date>
      <volume>5</volume>
      <issue>12</issue>
      <fpage>770</fpage>
      <lpage>777</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Endodontics focuses on the structure, function, diseases, and injuries of the dental pulp, along with the health and treatment of the periodontium, particularly regarding apical periodontitis caused by pulp infection. Endodontic treatment involves the chemical and mechanical preparation of root canals to facilitate the placement of biocompatible obturating materials. The primary goals are to eliminate microorganisms and organic debris that foster bacterial growth and to restore periodontal health. Treatment success is typically evaluated after one year, based on criteria such as symptom resolution, absence of sinus tracts, and normal radiographic findings. If lesions persist after this timeframe, outcomes are deemed uncertain, and retreatment is often advised after four years, per the European Society of Endodontology. Histological success is defined by the healing of periradicular tissues and the absence of inflammatory cells, with overall success rates ranging from 31% to 96%. Microorganisms within the root canals significantly undermine treatment outcomes, leading to pulp infection and persistent symptoms. Factors influencing success include broken instruments, anatomical variations in the tooth, and inadequate canal cleaning. Notably, success rates vary by tooth type, with three-canal teeth (90%) exhibiting higher success than two-canal (80%) and single-canal teeth (70%). Importantly, genetic variations also influence endodontic treatment outcomes by affecting disease susceptibility, progression, and therapeutic responses. Genetic predispositions can result in conditions such as persistent apical periodontitis. For instance, genes responsible for matrix metalloproteinases (MMPs) expression, which are involved in inflammation and bone remodeling, significantly impact the progression of periapical periodontitis and may alter treatment efficacy. Higher levels of MMPs may correlate with poor healing outcomes, underscoring the need for further research into the role of genetic factors in endodontics. This review aims to highlight the importance of genetic considerations in treatment efficacy and to advocate for additional scholarly investigation into this emerging field.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>endodontic treatment</kwd>
        <kwd> genetic variation</kwd>
        <kwd> root canal system</kwd>
        <kwd> matrix metalloproteinases</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>