<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="endocrinology" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">467</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2025.51207</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Endocrinology</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Influence of Root Canal Sealer Biocompatibility on Periapical Healing&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Alhazmi</surname>
            <given-names>Tariq Hassan</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Khawaji</surname>
            <given-names>Abdulelah Talal</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Almuways</surname>
            <given-names>Lulua Ahmed</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>14</day>
        <month>12</month>
        <year>2025</year>
      </pub-date>
      <volume>5</volume>
      <issue>12</issue>
      <fpage>760</fpage>
      <lpage>769</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Periapical lesions are the result of the colonization of microorganisms around the tooth root and the root canal. Before treatment, periapical lesions must be diagnosed, and endodontic status needs to be assessed. Diagnosis should be confirmed clinically and radiographically. Endodontic therapy involves treatment of root canal infection, cleaning and shaping of the root canals, and filling the root canal space. Root canal sealers play a crucial role in periapical healing by contributing to the hermetic obturation of the root canal system. Various root canal sealers are available with various biocompatibility, cytotoxicity, and physicochemical properties. However, no extensive comparative report on the impact of root canal sealers’ biocompatibility on periapical healing has been reported. This review aims to investigate the role of biocompatibility of different root canal sealers on periapical healing. Root canal sealers can be classified into zinc oxide eugenol-based sealers, zinc oxide-based sealers without eugenol, glass ionomer-based sealers, silicone-based sealers, resin-based sealers, calcium hydroxide-based sealers, and bioceramic sealers. Biocompatible, efficient sealers are those with good antimicrobial properties, good stimulation of tissue regeneration, positive impact on osteoblasts and osteoclasts, and low risk of inducing an inflammatory response. The recently developed bioceramic sealers have been associated with adequate clinical and biological outcomes; however, they have demonstrated potential neurotoxicity. Future studies should investigate the integration of various modifications in the composition of different sealers and their impact on periapical healing.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>Root canal sealer</kwd>
        <kwd> biocompatibility</kwd>
        <kwd> periapical healing</kwd>
        <kwd> periapical lesions</kwd>
        <kwd> endodontic therapy</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>