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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="allergy-and-immunology" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">466</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2025.51206</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Allergy and Immunology</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Full-Mouth Rehabilitation of a 9-Year-Old Child with Neurofibromatosis Type 1 and Renovascular Hypertension — A Multidisciplinary Approach under General Anesthesia. A Case Report.&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Alhuwayji</surname>
            <given-names>Zahra</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alshoraim</surname>
            <given-names>Mohammed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>AlShahrani</surname>
            <given-names>Omar</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Asiri</surname>
            <given-names>Naif</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Shetty</surname>
            <given-names>Deepa</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>10</day>
        <month>12</month>
        <year>2025</year>
      </pub-date>
      <volume>5</volume>
      <issue>12</issue>
      <fpage>753</fpage>
      <lpage>759</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Background: Neurofibromatosis Type 1 (NF1) is an autosomal-dominant neurocutaneous disorder caused by mutations in the NF1 gene located on chromosome 17q11.2, resulting in loss of neurofibromin function and subsequent tumor formation. The condition affects approximately 1 in 3,000 to 4,000 individuals worldwide and is characterized by variable systemic and orofacial manifestations, often appearing in childhood. Beyond its cutaneous and neural features, NF1 may also involve the vascular system; vascular dysplasia or renal-artery stenosis can occur, leading to renovascular hypertension, a serious systemic complication that increases cardiovascular and anesthetic risk. Importantly, oral manifestations may precede cutaneous lesions and can serve as early diagnostic indicators, underscoring the essential role of dental professionals in the early recognition and multidisciplinary management of NF1.&#13;
&#13;
Case Presentation: A 9-year-old boy diagnosed with NF1 presented with bilateral renal-artery stenosis, systemic hypertension, cardiomegaly, and impaired renal function. He was referred for comprehensive dental rehabilitation under general anesthesia because of extensive caries and limited cooperation. Extraoral examination revealed multiple caf__ampersandsigneacute;-au-lait macules, a convex facial profile, and lip incompetence. Intraoral findings included generalized gingival enlargement, delayed eruption of anterior teeth, remaining roots, and multiple carious lesions. Dental treatment involved restorations, pulpotomies, extractions, placement of stainless-steel crowns, and gingival-exposure surgery. Space maintenance was achieved with a Nance appliance in the maxilla and a lip bumper in the mandible. Postoperative recovery was uneventful, and follow-up visits demonstrated improved oral hygiene, healthy gingival tissues, and stable restorations.&#13;
&#13;
Conclusion: NF1 poses unique diagnostic and management challenges due to its multisystem involvement and anesthetic considerations, particularly when complicated by renovascular hypertension. Dental practitioners play a pivotal role in identifying oral manifestations, coordinating multidisciplinary medical care, and applying preventive strategies. Early recognition, individualized treatment planning, and structured long-term follow-up are essential to preserve oral health and enhance the quality of life of affected children.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>Neurofibromatosis Type 1</kwd>
        <kwd> pediatric dentistry</kwd>
        <kwd> oral manifestations</kwd>
        <kwd> renovascular hypertension</kwd>
        <kwd> general anesthesia</kwd>
        <kwd> multidisciplinary management</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>