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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="neurosurgery" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">444</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2025.51104</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Neurosurgery</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Spinal Cervical Meningiomas: An Integrative Review of Molecular Pathogenesis, Evolving Surgical Procedures, and Pathway to Personalized Management&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Abuhussain</surname>
            <given-names>Hamad Almarzouki</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>11</day>
        <month>11</month>
        <year>2025</year>
      </pub-date>
      <volume>5</volume>
      <issue>11</issue>
      <fpage>554</fpage>
      <lpage>568</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Spinal meningiomas are a major portion of primary spinal tumours that often affect the thoracic and cervical areas. The goal of this review is to provide an integrative and comprehensive synthesis of spinal cervical meningiomas, examining their molecular biology, classification, diagnostic strategies, surgical progression, and novel systemic treatment options. The Cochrane Library, Web of Science, PubMed/MEDLINE, and EMBASE database searches were conducted between August 2025 and December 2024. Based on inclusion/exclusion criteria and following a screening, full-text review, and data extraction procedure for English-language publications between January 2015 and August 2025, a narrative synthesis approach was employed to combine findings from different study designs and identify knowledge gaps. According to the 5th edition of the World Health Organization (WHO) Central Nervous System (CNS) tumors classification update from 2021, which included molecular markers (Telomerase reverse transcriptase (TERT) promoter mutations, Cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) deletions), spinal meningiomas differ from intracranial meningiomas in that they are more likely to have Neurofibromatosis Type 2 (NF2) mutations. Radiotherapy was more effective for subtotal resection, recurrence, or high-grade tumors; systemic therapies (targeted agents, immunotherapy, and Somatostatin receptor 2 (SSTR2)) are emerging; early surgery improves quality of life; advanced imaging (Magnetic Resonance imaging (MRI), Computed Tomography (CT), and Gallium-68 DOTATATE Positron Emission Tomography (68Ga DOTATATE PET)) improved diagnosis and follow-up; and surgery is the mainstay, with minimally invasive or endoscopic approaches reducing recurrence, complications, and Simpson Grade 1 or 2 resection associated with a lower rate of recurrence. This review showed that the understanding of the pathophysiology of spinal meningiomas, in addition to integrating molecular markers into the grading criteria, results in accurately predicting clinical behaviour. It suggested that molecular profiling, advanced imaging, minimally invasive surgery, and future tools like liquid biopsy and AI-based radiomics can all be combined for the early detection and diagnosis of spinal menangiomas, optimize treatment, and improve quality of life. Additionally, this review elucidates that a multimodal, personalized framework is the way of the future of managing cervical spinal meningiomas.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>Meningioma</kwd>
        <kwd> spinal</kwd>
        <kwd> cervical</kwd>
        <kwd> recurrence</kwd>
        <kwd> minimally invasive</kwd>
        <kwd> Simpson grade</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>