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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="dentistry" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">441</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2025.51101</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Dentistry</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Chronic Inflammation Effect on Nerve Regeneration in Dental Tissues&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Alsharif</surname>
            <given-names>Ainaa Abdulmoeen</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>AlSaif</surname>
            <given-names>Eatmad Ahmad</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alruqi</surname>
            <given-names>Hamoud Abdulrahman</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alhusayni</surname>
            <given-names>Abdullah Abdulkarim</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Algarni</surname>
            <given-names>Shaima Mohammed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alshahrani</surname>
            <given-names>Aseelah Abdullah</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>4</day>
        <month>11</month>
        <year>2025</year>
      </pub-date>
      <volume>5</volume>
      <issue>11</issue>
      <fpage>529</fpage>
      <lpage>538</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Nerve regeneration in dental tissues is crucial to restore function and preserve oral health. But the regenerative process is seriously hampered by chronic inflammation, which can be brought on by autoimmune diseases, trauma, or recurring infections. Neuronal apoptosis, delayed axonal regrowth, and compromised neurotrophic support are all caused by inflammatory mediators, including pro-inflammatory cytokines, reactive oxygen species, and matrix metalloproteinases. In dental tissues, these pathological alterations result in fibrosis, sensory dysfunction, and protracted healing. Neurotrophic factor supplementation, stem cell-based strategies, and targeted anti-inflammatory treatments may all aid in the restoration of nerve function in dental tissues that have been chronically inflamed, according to recent research. Developing successful regenerative therapies in dentistry requires an understanding of the relationship between inflammation and nerve regeneration. The mechanisms through which chronic inflammation hinders nerve regeneration are examined in this review, with particular attention paid to oxidative stress, extracellular matrix changes, and inflammatory signaling pathways.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>Nerve regeneration</kwd>
        <kwd> Chronic inflammation</kwd>
        <kwd> Oxidative stress</kwd>
        <kwd> Reactive Oxygen Species (ROS)</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>