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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="dentistry" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">427</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2025.50805 </article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Dentistry</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Neurogenic Inflammation and Its Role in Periodontal Disease&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>AlMozher</surname>
            <given-names>Hanan Abdullah</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Almuayli</surname>
            <given-names>Najla Abdurahman</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Almohaimeed</surname>
            <given-names>Majed Mohammad</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>26</day>
        <month>08</month>
        <year>2025</year>
      </pub-date>
      <volume>5</volume>
      <issue>8</issue>
      <fpage>418</fpage>
      <lpage>428</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Periodontal disease is an inflammatory disease caused predominantly by bacteria. Its prevalence is high among adults, especially mild and moderate forms. Periodontal disease is considered the second most widespread oral disease after dental caries. Periodontal prevalence can be affected by age, gender, ethnicity, and socioeconomic status. Furthermore, factors such as smoking, obesity, diabetes mellitus, and metabolic syndrome contribute strongly to periodontal disease. Neurogenic inflammation is involved in a variety of systemic diseases, including periodontitis. However, the role of neuroinflammation in periodontal diseases is unclear. Thus, this review aims to discuss the mechanistic pathways and therapeutic implications of neurogenic inflammation in periodontal diseases. Multiple studies found an association between neuropeptides and the development of periodontal diseases, as they found increased levels of neuropeptides in tissues and plasma of diseased patients. Studies also found a link between periodontal diseases and neurodegenerative diseases, including multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. Understanding these interactions may provide new therapeutic targets and improve both oral and systemic health outcomes.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>Periodontal Disease</kwd>
        <kwd> Periodontitis</kwd>
        <kwd> Neurogenic Inflammation</kwd>
        <kwd> Neuroinflammation</kwd>
        <kwd> Neuropeptides</kwd>
        <kwd> Neurodegenerative Diseases</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>