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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="pulmonology" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">380</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2024.41259</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Pulmonology</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Impact of Adherence to Treatment with Inhaled Corticosteroids/Long-Acting __ampersandsignbeta;-Agonists on Asthma Outcomes: A Systematic Review&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Almalki</surname>
            <given-names>Razan Ali</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alzahrani</surname>
            <given-names>Anas Hassan</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>31</day>
        <month>12</month>
        <year>2024</year>
      </pub-date>
      <volume>4</volume>
      <issue>12</issue>
      <fpage>1076</fpage>
      <lpage>1091</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Background: The management of asthma primarily involves a continuous regimen of inhaled corticosteroids (ICS) combined with long-acting beta-agonists (LABA). Non-adherence can lead to poorly controlled asthma, resulting in more frequent exacerbations, increased emergency room visits, and higher hospitalization rates. By systematically reviewing existing studies on adherence, this review aims to aggregate and analyze data to elucidate how variations in adherence levels to ICS/LABA impact asthma outcomes.&#13;
&#13;
Methods: A comprehensive search was conducted across multiple electronic databases, including PubMed, Scopus, ScienceDirect, Cochrane Library, and Web of Science. Peer-reviewed studies on asthma treatments involving ICS and/or LABAs focusing on assessing how adherence to these medications impact several key outcomes for patients. Screening, data extraction, and quality assessment were performed independently by two reviewers, with discrepancies resolved through discussion.&#13;
&#13;
Results: Findings from the included studies on asthma medication adherence reveal that higher adherence rates are linked to improved asthma management and reduced exacerbations. The adherence rates varied widely, with some studies reporting as high as 85% and others as low as 6%. Better adherence generally led to improved quality of life and fewer asthma-related exacerbations. Healthcare utilization costs also varied, with a range from $521 to $836. Barriers to adherence included fear of side effects and forgetfulness. Interventions such as enhanced education for both patients and providers, along with better medication management, particularly with combination inhalers, were suggested to improve adherence. Overall, consistent adherence to asthma medications is crucial for effective symptom control and reducing exacerbation rates.&#13;
&#13;
Conclusion: Future research should focus on developing and testing interventions specifically designed to address adherence barriers, additionally, exploring the impact of different inhaler combinations on long-term adherence and asthma outcomes could provide further insights.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>asthma</kwd>
        <kwd> outcome</kwd>
        <kwd> impact</kwd>
        <kwd> adherence</kwd>
        <kwd> ICS/LABA</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>