<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="dentistry" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">344</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2024.41223</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Dentistry</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Revascularization of Immature and Mature Teeth with Necrotic Pulp&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Alzahrani</surname>
            <given-names>Fadi Salem</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alshehri</surname>
            <given-names>Ali Mohammed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alshammari</surname>
            <given-names>Rayed Mayah</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alghamdi</surname>
            <given-names>Saleh Abdulrahman</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Bokhedher</surname>
            <given-names>Mayaseem Fadel</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alharbi</surname>
            <given-names>Nughaimish Naif</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>26</day>
        <month>12</month>
        <year>2024</year>
      </pub-date>
      <volume>4</volume>
      <issue>12</issue>
      <fpage>821</fpage>
      <lpage>828</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Revascularization is a regenerative endodontic procedure that focuses on revitalizing necrotic pulp tissue, offering significant advantages over traditional treatments such as apexification or root canal therapy. Immature teeth with open apices exhibit favorable conditions for revascularization, allowing for continued root development, dentinal wall thickening, and apical closure. This is facilitated by the presence of stem cells, growth factors, and an adequate scaffold, such as a blood clot, which supports cellular migration and tissue regeneration. Mature teeth, characterized by closed apices, present unique challenges due to limited regenerative capacity and restricted vascular access. Despite these limitations, the use of bioactive scaffolds, platelet concentrates, and advanced disinfection techniques has demonstrated potential in achieving partial regeneration and periapical healing. The success of revascularization depends on multiple factors, including microbial control, scaffold stability, the quality of coronal sealing, and patient-specific variables such as age and systemic health. Effective irrigation with agents like sodium hypochlorite and ethylenediaminetetraacetic acid (EDTA), combined with intracanal medicaments such as triple antibiotic paste, plays a critical role in reducing microbial load while maintaining cellular viability. Radiographic evaluations often reveal notable differences between immature and mature teeth, with the former showing more consistent structural improvements, such as root elongation and thickened dentinal walls, compared to the latter. Emerging strategies involving biomaterials, injectable scaffolds, and platelet-rich fibrin are advancing the predictability of outcomes, particularly for mature teeth. However, variability in clinical results, coupled with challenges in achieving true pulp-dentin regeneration, underscores the need for further research and innovation. Revascularization continues to evolve as a promising therapeutic approach, leveraging biological principles to optimize outcomes for patients with necrotic pulp in both immature and mature teeth.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>Revascularization</kwd>
        <kwd> necrotic pulp</kwd>
        <kwd> regenerative endodontics</kwd>
        <kwd> immature teeth</kwd>
        <kwd> mature teeth</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>