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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="dentistry" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">334</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2024.41213</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Dentistry</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Role of Triple Antibiotic Paste in Regenerative Endodontics&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Baghdadi</surname>
            <given-names>Loujain Fahad</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alshehri</surname>
            <given-names>Tariq Awadh</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Reda</surname>
            <given-names>Habib Ali</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Aldawood</surname>
            <given-names>Layla Ahmed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Abualsaud</surname>
            <given-names>Maria Hassan</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alamer</surname>
            <given-names>Hassan Mushabbab</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>9</day>
        <month>12</month>
        <year>2024</year>
      </pub-date>
      <volume>4</volume>
      <issue>12</issue>
      <fpage>729</fpage>
      <lpage>735</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Triple Antibiotic Paste (TAP), a combination of ciprofloxacin, metronidazole, and minocycline, plays a pivotal role in regenerative endodontics by providing effective antimicrobial action and creating an environment conducive to tissue regeneration. Its broad-spectrum activity targets diverse microbial populations, including biofilms, within the root canal system. This makes TAP particularly valuable in treating immature teeth with necrotic pulp, facilitating continued root development through stem cell recruitment, angiogenesis, and dentin-pulp tissue formation. The mechanism of TAP’s action is rooted in its ability to eradicate aerobic and anaerobic bacteria, disrupting biofilms and reducing inflammation. This not only supports tissue healing but also promotes the release of growth factors from dentin, which enhances stem cell differentiation and regenerative outcomes. However, challenges such as cytotoxicity, tooth discoloration, and the potential for antibiotic resistance have limited its widespread use. The inclusion of minocycline has been associated with staining, and high concentrations of TAP can adversely affect stem cell viability, prompting investigations into modified formulations and alternative medicaments. Emerging alternatives, including bioceramic materials, antimicrobial peptides, and nanoparticles, offer comparable antimicrobial efficacy while addressing the drawbacks of TAP. These materials provide biocompatibility, reduce the likelihood of resistance, and enhance regenerative potential. Innovations in drug delivery systems, such as controlled-release platforms, further improve the targeted application of these agents, ensuring sustained therapeutic activity within the root canal. Despite its limitations, TAP remains a cornerstone of regenerative endodontics, particularly for cases involving severe infection and immature root development. Advances in formulation and alternative approaches continue to expand its clinical utility, paving the way for more predictable and effective regenerative therapies. These efforts reflect the evolving landscape of endodontics, aiming to optimize patient outcomes while minimizing adverse effects associated with traditional antimicrobial strategies.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>triple antibiotic paste</kwd>
        <kwd> regenerative endodontics</kwd>
        <kwd> antimicrobial efficacy</kwd>
        <kwd> pulp revascularization</kwd>
        <kwd> tissue regeneration</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>