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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="forensic-medicine" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">327</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2024.41206</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Forensic Medicine</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Risk Factors and Early Warning Signs of Suicide Attempt for Patients on Sedatives and Antidepressants&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Emam</surname>
            <given-names>Abdulaziz Sulaiman</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Mujalid</surname>
            <given-names>Hani Safi</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alissa</surname>
            <given-names>Ibrahim Issa</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>AlZahrani</surname>
            <given-names>Abdulaziz Mohammed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alresheedi</surname>
            <given-names>Zayed Ozaywi</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Harshan</surname>
            <given-names>Aishah Ali</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alasmari</surname>
            <given-names>Abdulaziz Mohammad</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alnasser</surname>
            <given-names>Osama Mohammed</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>8</day>
        <month>12</month>
        <year>2024</year>
      </pub-date>
      <volume>4</volume>
      <issue>12</issue>
      <fpage>674</fpage>
      <lpage>682</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Suicide remains a significant global health concern, often linked to psychiatric conditions such as depression and anxiety. Sedative-hypnotic and antidepressant medications are widely prescribed to manage these conditions, yet their relationship with suicide attempts is complex and controversial. This narrative review explores the risk of suicide attempts associated with sedative-hypnotics, such as benzodiazepines and non-benzodiazepine sleep aids, and antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs). Evidence suggests that both classes of medications may elevate suicide risk in certain populations, especially during treatment initiation or abrupt discontinuation. Sedative-hypnotics are implicated in increased impulsivity and withdrawal symptoms, while antidepressants are associated with heightened suicidal ideation, particularly in youth under 25 years. The benefit-risk profile of these medications varies significantly with factors like dosage, treatment duration, and individual patient characteristics. Effective mitigation strategies include cautious prescribing, close monitoring, and integration of non-pharmacologic interventions. Future research should focus on longitudinal and controlled studies to better understand the mechanisms underlying these risks and to inform personalized treatment approaches.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>Suicide</kwd>
        <kwd> risk factors</kwd>
        <kwd> antidepressant</kwd>
        <kwd> sedatives</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>