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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="pediatrics" lang="en">
<front>
<journal-meta>
<journal-id journal-id-type="publisher">JOHS</journal-id>
<journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
<journal-title-group>
<journal-title>Journal of HealthCare Sciences</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">2231-2196</issn>
<issn pub-type="opub">0975-5241</issn>
<publisher>
<publisher-name>Radiance Research Academy</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">324</article-id>
<article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2024.41203</article-id>
<article-id pub-id-type="doi-url"/>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Pediatrics</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Diagnostic and Prognostic Significance of Blueberry Muffin Rash in Neonates
</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Alzanbagi</surname>
<given-names>Salah Mohammed</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Babonji</surname>
<given-names>Mohammed</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Alradha</surname>
<given-names>Abdulaziz</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mohamedsalih</surname>
<given-names>Alaa Abdallah</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Saleem</surname>
<given-names>Mohammed Yousef Al</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Junainah</surname>
<given-names>Mohammed Jamal</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mansour</surname>
<given-names>Nawaf Ali</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Alanazi</surname>
<given-names>Abdulrahman Obaid</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Almalki</surname>
<given-names>Hassan Meshal</given-names>
</name>
</contrib>
</contrib-group>
<pub-date pub-type="ppub">
<day>8</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>4</volume>
<issue>12</issue>
<fpage>650</fpage>
<lpage>657</lpage>
<permissions>
<copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
<copyright-year>2009</copyright-year>
<license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
<license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
</license>
</permissions>
<abstract>
<p>This review examines the diagnostic and prognostic significance of blueberry muffin rash in neonates, a distinctive dermatological presentation that often indicates serious underlying systemic conditions. The rash, characterized by purplish-blue macules or papules resembling small bruises, is associated with extramedullary hematopoiesis (EMH), a process where blood cell production occurs outside the bone marrow due to specific pathologic conditions. Common etiologies include congenital infections, particularly those in the TORCH complex—Toxoplasmosis, Other (such as syphilis), Rubella, Cytomegalovirus (CMV), and Herpes simplex virus—hematologic disorders like hemolytic disease of the newborn (HDN), and metabolic diseases, including lysosomal storage disorders. Each of these underlying conditions presents unique challenges and implications for the neonate__ampersandsign#39;s health. Early recognition of blueberry muffin rash, as it can prompt immediate and thorough evaluation to identify the underlying cause, which is crucial for guiding appropriate diagnostic testing and timely intervention. The prognostic implications vary significantly depending on the etiology; for example, congenital infections may lead to long-term complications such as sensorineural hearing loss or developmental delays, while hematologic disorders may require urgent interventions like blood transfusions. A comprehensive diagnostic approach, including maternal history assessment, laboratory investigations, and imaging studies, is essential for narrowing down potential causes. Management of blueberry muffin rash requires a multidisciplinary approach, involving pediatricians, neonatologists, dermatologists, and infectious disease specialists to ensure holistic care for affected infants. Immediate interventions depend on the specific diagnosis, while long-term follow-up is vital for monitoring developmental progress and addressing potential complications. Additionally, the review highlights the importance of providing family education and psychosocial support to help parents navigate the complexities of care associated with their child__ampersandsign#39;s condition. Finally, preventive measures, including vaccination and public health education, are crucial for reducing the incidence of congenital infections that can lead to blueberry muffin rash.
</p>
</abstract>
<kwd-group>
<kwd>blueberry muffin rash</kwd>
<kwd> neonates</kwd>
<kwd> congenital infections</kwd>
<kwd> hematologic disorders</kwd>
<kwd> diagnosis</kwd>
<kwd> management</kwd>
</kwd-group>
</article-meta>
</front>
</article>