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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="dentistry" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">318</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2024.41108</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Dentistry</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Evaluation of Biomaterials Used in Guided Tissue Regeneration&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Munshi</surname>
            <given-names>Maha Assad</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alsaleh</surname>
            <given-names>Fai Adel</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Aljehani</surname>
            <given-names>Nassreen Yousef</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Almusaad</surname>
            <given-names>Mashael Mohammed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alolaian</surname>
            <given-names>Reem Khalid</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alshammari5</surname>
            <given-names>Amjad Zayed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Eissa</surname>
            <given-names>Renad Hamza</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>25</day>
        <month>11</month>
        <year>2024</year>
      </pub-date>
      <volume>4</volume>
      <issue>11</issue>
      <fpage>609</fpage>
      <lpage>615</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Guided tissue regeneration (GTR) is a key technique in periodontal therapy, aimed at restoring lost periodontal structures such as bone, periodontal ligament, and cementum. Biomaterials play a crucial role in the success of GTR by serving as barriers that selectively allow tissue regeneration. The choice of biomaterials used in GTR has evolved over the years, encompassing non-resorbable options like expanded polytetrafluoroethylene (ePTFE) and resorbable materials such as collagen-based membranes and synthetic polymers. Each type of biomaterial presents unique benefits and limitations. Non-resorbable materials provide excellent mechanical stability but require a second surgery for removal, while resorbable membranes eliminate this need but may degrade unpredictably, affecting regeneration outcomes. Biocompatibility and degradation properties of these materials are central to their effectiveness. Natural biomaterials, such as collagen, offer superior biocompatibility, mimicking the extracellular matrix to promote cell attachment. However, synthetic materials, including polylactic acid (PLA) and polyglycolic acid (PGA), offer more predictable degradation rates, but their byproducts can cause localized inflammation, posing challenges to their clinical application. Composite biomaterials are emerging as a potential solution, combining the strengths of natural and synthetic materials to optimize both biocompatibility and mechanical support. Clinical applications of GTR include the treatment of infrabony and furcation defects, as well as gingival recession. GTR has shown significant potential in these areas, with varying degrees of success depending on defect type and patient factors. Challenges in biomaterial development persist, particularly in balancing mechanical stability with bioactivity, and achieving predictable degradation rates. Future research is likely to focus on the incorporation of bioactive agents and the use of nanotechnology to create smart biomaterials that can dynamically respond to the healing environment, enhancing tissue regeneration and clinical outcomes.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>Guided tissue regeneration</kwd>
        <kwd> expanded polytetrafluoroethylene</kwd>
        <kwd> polylactic acid</kwd>
        <kwd> polyglycolic acid</kwd>
        <kwd> biomaterials</kwd>
        <kwd> periodontic</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>