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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="allergy-and-immunology" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">284</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2024.40806</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Allergy and Immunology</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Non-adherence to Medication and Associated Factors Among Type 2 Diabetes: Systematic Review&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Alzaher</surname>
            <given-names>Sakinah Hassan</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>14</day>
        <month>08</month>
        <year>2024</year>
      </pub-date>
      <volume>4</volume>
      <issue>8</issue>
      <fpage>311</fpage>
      <lpage>326</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Non-adherence to medication among Type 2 diabetes mellitus (T2DM) patients is a complex and multifactorial issue, with various contributing factors. Patient-related factors such as socioeconomic status, health literacy, beliefs and attitudes toward medication, and psychosocial factors like depression, anxiety, and stress can all play a role. Healthcare system-related factors can also contribute to non-adherence. A systematic review was conducted to identify and synthesize the available evidence on non-adherence to medication and related factors among T2DM patients. Included studies that report medication non-compliance and related variables in T2DM individuals were used. Excluded studies had non-original investigations, non-human investigations, incomplete data, and abstract-only articles. Electronic databases were searched and eligible studies were selected. Data extraction was conducted independently by two researchers and quality assessment was performed using standardized tools. The search identified 8 studies involving 2030 patients published from 2009 to 2024. These studies revealed varied rates of medication non-adherence ranging from 10.3% to 77.3%. The research showed diverse findings, indicating that older age consistently acts as a protective factor against non-adherence, particularly among individuals aged over 60. Only one study indicated a significant association with male gender. Education level yielded mixed results. Additionally, one study highlighted a significant relationship between depressive symptoms and non-adherence. Employment status exhibited varying associations. Overall, these findings highlight the complex interplay of demographic and treatment-related factors influencing adherence to diabetic medication. The studies reviewed revealed wide-ranging rates of non-adherence, illustrating a significant challenge in managing this chronic condition effectively. These findings underscore the need for personalized approaches in diabetes management, addressing not only clinical factors but also socio-demographic and psychological influences to improve medication adherence and ultimately health outcomes for patients. Future research should focus on comprehensive strategies that integrate these diverse factors to optimize treatment adherence in individuals with T2DM.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>non-adherence</kwd>
        <kwd> medication</kwd>
        <kwd> diabetes</kwd>
        <kwd> association</kwd>
        <kwd> significant</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>