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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="emergency-medicine-and-critical-care" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">282</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2024.40804</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Emergency Medicine and Critical Care</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>The Significance of Nitroglycerin in Emergency Medicine Across Multidisciplinary Conditions: A Comprehensive Systematic Review&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Aldahash</surname>
            <given-names>Ahmed Abdulrahman</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>AlGhazwani</surname>
            <given-names>Abdulaziz Saud</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>7</day>
        <month>08</month>
        <year>2024</year>
      </pub-date>
      <volume>4</volume>
      <issue>8</issue>
      <fpage>284</fpage>
      <lpage>295</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Background: Nitroglycerin, a fast-acting vasodilator, is often used in the emergency department as a first-line treatment for angina and chest pain caused by acute coronary syndrome. It can also be used to treat other conditions such as acute heart failure, pulmonary edema, and aortic dissection. In patients with decompensated congestive heart failure with acute pulmonary edema, intravenous bolus nitroglycerin can reduce the requirement for intubation, intensive care admission rate and hospital duration of stay. Through this systematic review, we aim to elaborately analyse the existing literature to define the beneficial role of the administration of nitroglycerine across diverse cohorts of patients reporting to emergency medicine settings.&#13;
&#13;
Methods: Our study aimed to assess the significance of nitroglycerine in emergency medicine settings for various multidisciplinary conditions. As a result, we included original studies that defined the role and utilization of nitroglycerine across various diseases among emergency medicine patients specifically. Studies including the pediatric population were excluded. Newcastle-Ottoman Castle and Cochrane risk of bias assessment tools were utilized to assess the quality of included studies.&#13;
&#13;
Results: Final inclusion incorporated a total of 6 studies encompassing 9452 patients, published between 2006 and 2022. The findings highlight the beneficial role of nitroglycerine in the management of various conditions. The majority of the patients presented with heart failure followed by cases of hypertension, pulmonary oedema, circulatory shock, stroke, acute coronary syndrome or myocardial infarction, and chest pain. The utilization of nitroglycerine resulted in significant symptomatic relief and improvement in the patient__ampersandsign#39;s condition.&#13;
&#13;
Conclusion: This review extensively explores the role and utilization of nitroglycerine for the management of diverse conditions treated in emergency settings. Nitroglycerine offers a wide range of clinical applications in the emergency department and is reinforced by established guidelines for angina, heart failure, acute coronary syndrome, pulmonary edema and other conditions. Other uses for nitroglycerine exist; however, most indications suffer from a lack of stringent, randomized trial evidence, emphasizing the need for more research into this time-tested medicine.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>nitroglycerine</kwd>
        <kwd> emergency</kwd>
        <kwd> management</kwd>
        <kwd> heart failure</kwd>
        <kwd> pulmonary edema</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>