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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="hematology" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">256</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2024.40107</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Hematology</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Epidemiology, Clinical Presentation, and Treatment of Thrombotic Thrombocytopenic Purpura&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Alharbi</surname>
            <given-names>Samar</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Almutairi</surname>
            <given-names>Khalid</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alashhab</surname>
            <given-names>Mohannad</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Otayn</surname>
            <given-names>Abdullah</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alamri</surname>
            <given-names>Hind</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alzahrani</surname>
            <given-names>Ahmed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alqahtani</surname>
            <given-names>Abdulaziz</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>AlQurayyan</surname>
            <given-names>Abdullah</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Radhwan</surname>
            <given-names>Nafisah Al</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Kariri</surname>
            <given-names>Shatha</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Almuhaini</surname>
            <given-names>Mohammed</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname/>
            <given-names/>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>13</day>
        <month>01</month>
        <year>2024</year>
      </pub-date>
      <volume>4</volume>
      <issue>1	</issue>
      <fpage>56</fpage>
      <lpage>63</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Thrombotic Thrombocytopenic Purpura (TTP) is a critical medical condition characterized by thrombocytopenia, hemolytic anemia, and organ damage due to microvascular clotting. This review delves into TTP__ampersandsign#39;s epidemiology, clinical presentation, and treatment methods. Advances in understanding the disease__ampersandsign#39;s pathophysiology have allowed significant improvements in management strategies. The shift from traditional therapies like therapeutic plasma exchange and corticosteroids to innovative, targeted treatments such as rituximab and caplacizumab marks a significant positive effect. These novel therapies offer less invasive, patient-centric approaches, heralding a new era in TTP treatment. The review also highlights the future directions of TTP research and therapy, emphasizing the need for continued innovation and tailored care strategies. This evolution in TTP management underscores a move towards personalized medicine, focusing on improving outcomes and the quality of life for patients. The dynamic nature of TTP treatment is shifting towards more effective, patient-focused therapeutic options, reflecting the ongoing advancements in the field.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>Thrombotic Thrombocytopenic Purpura</kwd>
        <kwd> Microvascular clotting</kwd>
        <kwd> Therapeutic plasma exchange</kwd>
        <kwd> Rituximab</kwd>
        <kwd> Caplacizumab</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>