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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="emergency-medicine-and-critical-care" lang="en">
<front>
<journal-meta>
<journal-id journal-id-type="publisher">JOHS</journal-id>
<journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
<journal-title-group>
<journal-title>Journal of HealthCare Sciences</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
</journal-title-group>
<issn pub-type="ppub">2231-2196</issn>
<issn pub-type="opub">0975-5241</issn>
<publisher>
<publisher-name>Radiance Research Academy</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">233</article-id>
<article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2023.31216</article-id>
<article-id pub-id-type="doi-url"/>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Emergency Medicine and Critical Care</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Exploring the Major Triggers of Seizures Due to Drug Overdose and Their Corresponding Countermeasures
</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Aljefri</surname>
<given-names>Ahmed</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Alkhateeb</surname>
<given-names>Abdulrahman</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Alkhaibari</surname>
<given-names>Abdulrahman</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gabban</surname>
<given-names>Rawabi</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Alamin</surname>
<given-names>Osamah</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Alribh</surname>
<given-names>Fatimah</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Alanazi</surname>
<given-names>Fahad</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Abualiat</surname>
<given-names>Tameem</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Alshehab</surname>
<given-names>Sarah</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Aljuhani</surname>
<given-names>Ghada</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Diqarshawi</surname>
<given-names>Aman</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Altalhi</surname>
<given-names>Abdulaziz</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Albeladi</surname>
<given-names>Adel</given-names>
</name>
</contrib>
</contrib-group>
<pub-date pub-type="ppub">
<day>30</day>
<month>11</month>
<year>-0001</year>
</pub-date>
<volume>3</volume>
<issue>12</issue>
<fpage>667</fpage>
<lpage>673</lpage>
<permissions>
<copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
<copyright-year>2009</copyright-year>
<license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
<license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
</license>
</permissions>
<abstract>
<p>Seizures in the context of drug overdose present a complex challenge, primarily arising from central nervous system (CNS) stimulation, electrolyte imbalances, reduced seizure thresholds, drug interactions, hepatic impairment, and direct CNS toxicity. Commonly implicated substances include stimulants like amphetamines, cocaine, and ecstasy, as well as prescription medications like opioids and benzodiazepines. Management strategies include the use of benzodiazepines to reduce neuronal activity, fluid resuscitation, electrolyte replacement therapy, and specific interventions for drug interactions and hepatic impairment. The clinical manifestations of drug-induced seizures are diverse, including convulsions, altered consciousness, autonomic dysfunction, focal neurological deficits, and in severe cases, status epilepticus. These manifestations require swift and targeted clinical interventions to minimize patient morbidity and mortality. This comprehensive review addresses the significant public health concern of drug overdose-related seizures, focusing on the triggers and appropriate countermeasures. The management of drug overdose-induced seizures is a nuanced and multifaceted process. It demands a coordinated effort from healthcare professionals, integrating prevention strategies, patient-centered care, and continuous monitoring to ensure effective management and long-term recovery.
</p>
</abstract>
<kwd-group>
<kwd>Drug overdose seizures</kwd>
<kwd> Central nervous system stimulation</kwd>
<kwd> Anticonvulsant medications</kwd>
<kwd> Multidisciplinary management</kwd>
<kwd> Status epilepticus</kwd>
</kwd-group>
</article-meta>
</front>
</article>